Neutrophils in Gliomas
نویسندگان
چکیده
منابع مشابه
Neutrophils in Gliomas
Neutrophils are the most abundant white blood cells and are the first recruited to inflammatory sites. Neutrophils are an important component of the tumor stroma and can exert both anti-tumoral and pro-tumoral activities, depending on their maturation and activation state. In human gliomas, the number of circulating and infiltrating neutrophils correlates with the severity of the disease, indic...
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1 Medical Oncology 1, Veneto Institute of Oncology-IRCCS, Via Gattamelata 64, 35128 Padua, Italy 2 Neurosurgery Department, Padua Hospital, 35128 Padua, Italy 3 Department of Neuro-Oncology, UPMC, GH Pitié-Salpétrière, 75005 Paris, France 4DBBS, National Neurological Institute C. Mondino, University of Pavia, 27100 Pavia, Italy 5 Neurology Unit, National Cancer Unit, Regina Elena, 00144 Rome, I...
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In general, studies reveal that cancer arises through genetic and epigenetic alterations that affect specific genes within a given cell type. These changes involve a gain of function when the alterations involve oncogenes, a loss of function when the target genes are tumor suppressor genes. Thus, both genetic and epigenetic changes promote the instability of cellular homeostasis (Bello & Rey, 2...
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ژورنال
عنوان ژورنال: Frontiers in Immunology
سال: 2017
ISSN: 1664-3224
DOI: 10.3389/fimmu.2017.01349